Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 2/20 | 0.53 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NT5E | P21589 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | GLI1 | P08151 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15713694 | 0.86 | GPBAR1 (0.55) | TOP2AGPBAR1LMNANT5ESMN1; SMN2 | |
| SCHEMBL17124246 | 0.85 | PTPN1 (0.63) | TOP2APTPN1CES2CES1PTGES | |
| SCHEMBL15417851 | 0.79 | GPBAR1 (0.61) | PTPN1CES2CES1GPBAR1LMNA | |
| Lupenone SCHEMBL27218586 | 0.79 | GPBAR1 (0.75) | TOP2APTPN1CES2CES1PTGES | |
| Lupenone SCHEMBL13908727 | 0.79 | GPBAR1 (0.75) | TOP2APTPN1CES2CES1PTGES | |
| Lupenone SCHEMBL13908802 | 0.79 | GPBAR1 (0.75) | TOP2APTPN1CES2CES1PTGES | |
| Lupenone SCHEMBL13692854 | 0.79 | GPBAR1 (0.75) | TOP2APTPN1CES2CES1PTGES | |
| Lupenone SCHEMBL13851777 | 0.79 | GPBAR1 (0.75) | TOP2APTPN1CES2CES1PTGES | |
| Lupenone SCHEMBL1224027 | 0.79 | GPBAR1 (0.75) | TOP2APTPN1CES2CES1PTGES | |
| SCHEMBL17124248 | 0.76 | PTGES (0.52) | TOP2APTPN1CES2CES1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150272922-A1 | Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof | BIONICHE ANIMAL HEALTH USA, INC. | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150272922-A1 | Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof | NR3C1, NR5A1, NR3C2 | TOP2A 982/4885PTPN1 855/4885CES2 2448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.