Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | STIM1 | Q13586 | 7/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 7/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | TRPC1 | P48995 | 3/20 | 0.44 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712001 | 0.91 | MEN1 (0.56) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL2710339 | 0.91 | KMT2A (0.54) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL17125370 | 0.89 | MEN1 (0.57) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL17125398 | 0.86 | MAPKAPK2 (0.57) | MEN1NPC1RAB9AKMT2AMAPKAPK2 | |
| SCHEMBL182309 | 0.85 | MAPKAPK2 (0.61) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL2710501 | 0.83 | MEN1 (0.60) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL2708635 | 0.83 | MEN1 (0.64) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL182504 | 0.83 | MEN1 (0.57) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL17125387 | 0.83 | MEN1 (0.60) | MEN1NPC1RAB9AKMT2ASTIM1 | |
| SCHEMBL2709532 | 0.82 | NPC1 (0.54) | MEN1NPC1RAB9AKMT2ASTIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | PTC THERAPEUTICS, INC. (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274674-A1 | PYRAZOLE OR TRIAZOLE COMPOUNDS AND THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING SOMATIC MUTATION-RELATED DISEASES | UPF1, RNMT, VHL | MEN1 3684/4885NPC1 1560/4885RAB9A 3615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.