RNMT

mRNA cap guanine-N(7) methyltransferase · O43148 · RNMT on Sugi Atlas →

3,139 patent compounds predicted against RNMT, 2,800 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13836236	0.75	2/20
SCHEMBL13966944	0.75	2/20
Adenosine (SCHEMBL6408967)	0.75	2/20
Adenosine (SCHEMBL6408986)	0.75	2/20
Adenosine (SCHEMBL1858293)	0.70	2/20
Adenosine (SCHEMBL8013453)	0.69	2/20
Adenosine (SCHEMBL8013455)	0.69	2/20
Adenosine (SCHEMBL9805161)	0.64	2/20
SCHEMBL13966924	0.61	2/20
SCHEMBL4661777	0.58	2/20
SCHEMBL13976429	0.56	2/20
SCHEMBL13966923	0.55	2/20
SCHEMBL13966927	0.55	2/20
SCHEMBL13976309	0.55	2/20
Inosine (SCHEMBL8446027)	0.54	2/20
Inosine (SCHEMBL8446030)	0.54	2/20
Levothyroxine (SCHEMBL4316766)	0.54	2/20
SCHEMBL13966928	0.54	2/20
SCHEMBL13966930	0.53	2/20
SCHEMBL13966933	0.53	2/20

Clinical trials — most relevant to RNMT by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Combination Chemotherapy and Radiation Therapy Plus Surgery in Treating Patients With Advanced Cancer of the Pancreas	PHASE2	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction	PHASE2	COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Human Telomerase Reverse Transcriptase Messenger RNA (hTERT mRNA) Transfected Dendritic Cell Vaccines	PHASE1/PHASE2	WITHDRAWN
Decitabine, Vorinostat, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome	PHASE1	COMPLETED
Gemcitabine and Radiation Therapy in Treating Patients With Locally Advanced Upper Gastrointestinal Cancer	PHASE1	COMPLETED
Azacitidine in Combination With Mitoxantrone, Etoposide Phosphate, and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia	PHASE1	COMPLETED
5-Fluoro-2'-Deoxcyctidine and Tetrahydrouridine to Treat Patients With Advanced Cancer	PHASE1	COMPLETED
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
Using the Epitranscriptome to Diagnose and Treat Gliomas	nan	RECRUITING
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)	nan	UNKNOWN
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study	nan	NOT_YET_RECRUITING
Search for Bovine miRNA Transference to Humans	nan	COMPLETED
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Effect of DNMT SNPs on DNA Methylation in Primary ITP	nan	UNKNOWN
miR-155 Expression in Episodic and Chronic Migraine	nan	UNKNOWN
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Study of Specimens From Young Patients With Neuroblastoma	nan	COMPLETED
Role and Interactions of Adenosine, Receptors, Methionine Cycle Nutritional, Metabolic and Genetic Determinants in the Onset of Atrial Fibrillation in Normal Heart	nan	UNKNOWN
Prognosis of METTL-14 in Endometrial Carcinoma	nan	NOT_YET_RECRUITING
MiRNA223 and HMGB1 as Apredictos for Drug Resistant Epilepsy	nan	UNKNOWN
Impact of Weight Loss on the Human Sperm Epitranscriptome	nan	ACTIVE_NOT_RECRUITING
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Inflammatory Proteins in Familial Mediterranean Fever During Attack and Remission	nan	WITHDRAWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Methylation of DNA in Children and Adolescents With Type 1 Diabetes Mellitus (METHYLDIAB)	nan	COMPLETED
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RNMT binder may also engage these)

Protein	Name	Similarity
Q4R7K1	—	1.000	Q4R7K1 →
Q5U2U7	—	0.999	Q5U2U7 →
Q9I8S2	—	0.989	Q9I8S2 →
Q9D0L8	—	0.988	Q9D0L8 →
Q28FT4	—	0.988	Q28FT4 →
Q1MTD3	—	0.981	Q1MTD3 →
Q8N1G2	—	0.978	Q8N1G2 →
Q66J91	—	0.977	Q66J91 →
Q5R981	—	0.977	Q5R981 →
Q4KLT3	—	0.976	Q4KLT3 →
Q9DBC3	—	0.976	Q9DBC3 →
Q9NUP7	—	0.976	Q9NUP7 →
Q5U2Z5	—	0.976	Q5U2Z5 →
A4IIA7	—	0.975	A4IIA7 →
MAP3K5	Mitogen-activated protein kinase kinase kinase 5	0.975	landscape →
Q6GN29	—	0.975	Q6GN29 →
Q3SXY8	—	0.974	Q3SXY8 →
Q8NHH9	—	0.974	Q8NHH9 →
O35099	—	0.974	O35099 →
Q9BXW6	—	0.974	Q9BXW6 →
Q5ZLV4	—	0.974	Q5ZLV4 →
Q8GT06	—	0.974	Q8GT06 →
Q7TPQ3	—	0.974	Q7TPQ3 →
Q95LN3	—	0.973	Q95LN3 →
A2VE39	—	0.973	A2VE39 →
Q0P410	—	0.973	Q0P410 →
F1ND48	—	0.973	F1ND48 →
Q8NE18	—	0.972	Q8NE18 →
Q5W9E7	—	0.972	Q5W9E7 →
D2HRF1	—	0.972	D2HRF1 →