Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712735 | 0.94 | ALDH1A1 (0.57) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL1713488 | 0.79 | ALDH1A1 (0.62) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL1713056 | 0.74 | MAPK1 (0.67) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL1713223 | 0.73 | MAPK1 (0.63) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL7829590 | 0.73 | ALDH1A1 (0.52) | ALDH1A1POLBCYP2C19SMN1; SMN2 | |
| SCHEMBL1713300 | 0.72 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL7832350 | 0.72 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1POLBCYP2C19 | |
| SCHEMBL5244127 | 0.72 | MEN1 (0.72) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL5282637 | 0.72 | MEN1 (0.72) | MEN1KMT2AALDH1A1MAPK1POLB | |
| SCHEMBL5243826 | 0.72 | MEN1 (0.72) | MEN1KMT2AALDH1A1MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252587-B1 | PIPERIDINE SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | claimed |
| EP-2252587-B1 | PIPERIDINE SULFONAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-20 | — | — | EP | disclosed |