SCHEMBL1713346

SCHEMBL1713346

COc1ccc(Cc2cc([C@]3(O)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc2Cl)cc1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 20/20 0.59
SLC5A1 P13866 10/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30324356 1.00 SLC5A2 (0.59) SLC5A2SLC5A1
SCHEMBL19183410 1.00 SLC5A2 (0.59) SLC5A2SLC5A1
SCHEMBL4640886 0.94 SLC5A2 (0.66) SLC5A2SLC5A1
SCHEMBL4640899 0.94 SLC5A2 (0.66) SLC5A2SLC5A1
SCHEMBL4595400 0.92 SLC5A2 (0.55) SLC5A2SLC5A1
SCHEMBL4639844 0.91 SLC5A2 (0.55) SLC5A2SLC5A1
SCHEMBL4640420 0.91 SLC5A2 (0.55) SLC5A2SLC5A1
SCHEMBL4593802 0.91 SLC5A2 (0.52) SLC5A2SLC5A1
SCHEMBL4595647 0.91 SLC5A2 (0.57) SLC5A2SLC5A1
SCHEMBL4595282 0.91 SLC5A2 (0.52) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11548906-B2 Processes for the preparation of SGLT-2 inhibitors, intermediates thereof EMMENNAR PHARMA PRIVATE LIMITED (IN) 2023-01-10 US disclosed
US-10913762-B2 Process for the preparation of D-glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl] oxy]phenyl] methyl] phenyl]-, (1S) and its crystalline forms thereof MSN LABORATORIES PRIVATE LIMITED (IN) 2021-02-09 US disclosed
US-10913762-B2 Process for the preparation of D-glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl] oxy]phenyl] methyl] phenyl]-, (1S) and its crystalline forms thereof MSN LABORATORIES PRIVATE LIMITED (IN) 2021-02-09 US disclosed
US-20200331946-A1 PROCESSES FOR THE PREPARATION OF SGLT-2 INHIBITORS, INTERMEDIATES THEREOF EMMENNAR PHARMA PRIVATE LIMITED, (IN) 2020-10-22 US disclosed
US-20190040094-A1 PROCESS FOR THE PREPARATION OF D-GLUCITOL, 1,5-ANHYDRO-1-C-[4-CHLORO-3-[[4-[[(3S)-TETRAHYDRO-3-FURANYL] OXY]PHENYL] METHYL] PHENYL]-, (1S) AND ITS CRYSTALLINE FORMS THEREOF MSN LABORATORIES PRIVATE LIMITED (IN) 2019-02-07 US disclosed
US-20190040094-A1 PROCESS FOR THE PREPARATION OF D-GLUCITOL, 1,5-ANHYDRO-1-C-[4-CHLORO-3-[[4-[[(3S)-TETRAHYDRO-3-FURANYL] OXY]PHENYL] METHYL] PHENYL]-, (1S) AND ITS CRYSTALLINE FORMS THEREOF MSN LABORATORIES PRIVATE LIMITED (IN) 2019-02-07 US disclosed
WO-2017130217-A1 THE PRESENT INVENTION RELATES TO PROCESS FOR THE PREPARATION OF D-GLUCITOL, 1,5- ANHYDRO-1-C-[4-CHLORO-3-[[4-[[(3S)-TETRAHYDRO-3-FURANYL] OXY]PHENYL] METHYL]PHENYL]-, (1S) AND ITS CRYSTALLINE FORMS THEREOF. MSN LABORATORIES PRIVATE LIMITED (IN) 2017-08-03 WO disclosed
EP-1989191-B1 GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE BOEHRINGER INGELHEIM INT (DE) 2011-07-20 EP disclosed
US-7745414-B2 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-06-29 US disclosed
EP-1989191-A1 GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE Boehringer Ingelheim International GmbH (DE) 2008-11-12 EP disclosed
US-7393836-B2 D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-07-01 US disclosed
US-20080058379-A1 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2008-03-06 US disclosed
EP-1765842-B1 D-XYLOPYRANOSYL-SUBSTITUTED PHENYLS, MEDICAMENTS CONTAINING SAID COMPOUNDS, THE USE THEREOF, AND METHODS FOR PRODUCING THE SAME BOEHRINGER INGELHEIM INT (DE) 2008-01-09 EP disclosed
WO-2007093610-A1 GLUCOPYRANOSYL-SUBSTITUTED BENZONITRILE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-08-23 WO disclosed
US-20060009400-A1 D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080058379-A1 Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture UGGT1, GALE, UGT1A4 SLC5A2 4/4885SLC5A1 5/4885
US-20060009400-A1 D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture SLC5A1, SLC5A2, SLC2A1 SLC5A2 2/4885SLC5A1 1/4885
US-20190040094-A1 PROCESS FOR THE PREPARATION OF D-GLUCITOL, 1,5-ANHYDRO-1-C-[4-CHLORO-3-[[4-[[(3S)-TETRAHYDRO-3-FURANYL] OXY]PHENYL] METHYL] PHENYL]-, (1S) AND ITS CRYSTALLINE FORMS THEREOF ALG1, FBP1, DAD1 SLC5A2 98/4885SLC5A1 12/4885
US-11548906-B2 Processes for the preparation of SGLT-2 inhibitors, intermediates thereof SLC5A2, SLC5A1, SLC2A4 SLC5A2 1/4885SLC5A1 2/4885
US-10913762-B2 Process for the preparation of D-glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl] oxy]phenyl] methyl] phenyl]-, (1S) and its crystalline forms thereof ALG1, FBP1, DAD1 SLC5A2 98/4885SLC5A1 12/4885
US-20200331946-A1 PROCESSES FOR THE PREPARATION OF SGLT-2 INHIBITORS, INTERMEDIATES THEREOF SLC5A2, SLC5A1, SLC2A4 SLC5A2 1/4885SLC5A1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.