Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.64 |
| ▸ | CTSV | O60911 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 6/20 | 0.44 |
| ▸ | HTR1B | P28222 | 6/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14546539 | 0.92 | NR1I2 (0.55) | NR1I2CTSVCTSLCYP2D6CYP2C9 | |
| SCHEMBL14608693 | 0.89 | NR1I2 (0.53) | NR1I2CTSVCTSLCYP2D6CYP2C9 | |
| SCHEMBL10040975 | 0.89 | NR1I2 (0.51) | NR1I2CTSVCTSLCYP2D6CYP2C9 | |
| SCHEMBL12966419 | 0.88 | NR1I2 (0.60) | NR1I2CTSVCTSLCYP2D6CYP2C9 | |
| SCHEMBL14608490 | 0.86 | NR1I2 (0.50) | NR1I2CTSVCTSLCYP2D6CYP2C9 | |
| SCHEMBL12966402 | 0.84 | CTSV (0.51) | NR1I2CTSVCTSLCYP2D6CYP2C9 | |
| SCHEMBL13922106 | 0.83 | NR1I2 (0.54) | NR1I2CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL12966379 | 0.82 | MAPT (0.50) | NR1I2CTSVCTSLCYP2D6CYP2C9 | |
| SCHEMBL4565516 | 0.82 | ALOX5 (0.61) | NR1I2CYP2D6CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL10605076 | 0.80 | ALOX5 (0.70) | NR1I2CTSVCTSLCYP2D6ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-8889896-B2 | Process for the preparation of bazedoxifene acetate and intermediates thereof | Divi's Laboratories, Ltd. (IN) | 2014-11-18 | — | — | US | disclosed |
| US-20140329784-A1 | 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLE AND ESTROGEN FORMULATIONS | WYETH LLC (US) | 2014-11-06 | — | — | US | disclosed |
| US-8815934-B2 | 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations | WYETH LLC (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130289296-A1 | NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | DIVI'S LABORATORIES LTD. (IN) | 2013-10-31 | — | — | US | disclosed |
| US-20120330008-A1 | NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | DIVI'S LABORATORIES LIMITED (IN) | 2012-12-27 | — | — | US | disclosed |
| US-20120252769-A1 | 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLE AND ESTROGEN FORMULATIONS | WYETH LLC (US) | 2012-10-04 | — | — | US | disclosed |
| EP-2118058-B9 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | ZENTIVA KS (CZ) | 2012-03-28 | — | — | EP | disclosed |
| EP-2426105-A1 | Process for the preparation of 5-benzyloxy-2-(4-benzyloxyphenyl)-3-methyl-1h-indole | Divi's Laboratories Limited (IN) | 2012-03-07 | — | — | EP | disclosed |
| US-8034807-B2 | Salts of bazedoxifene | ZENTIVA K.S. (CZ) | 2011-10-11 | — | — | US | disclosed |
| US-20090176764-A1 | 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLES AS ESTROGENIC AGENTS | WYETH (US) | 2009-07-09 | — | — | US | disclosed |
| WO-2009012734-A2 | NEW SALTS OF BAZEDOXIFENE | ZENTIVA A.S. (CZ) | 2009-01-29 | — | — | WO | disclosed |
| US-7449455-B2 | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | WYETH (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2008098527-A1 | METHOD FOR THE PREPARATION OF 5-BENZYLOXY-2-(4-BENZYLOXPHENYL)-3-METHYL-1H-INDOLE | ZENTIVA A.S. (CZ) | 2008-08-21 | — | — | WO | disclosed |
| US-20080021017-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | WYETH (US) | 2008-01-24 | — | — | US | disclosed |
| US-7247624-B2 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | WYETH (US) | 2007-07-24 | — | — | US | disclosed |
| US-20070142361-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations | WYETH (US) | 2007-06-21 | — | — | US | disclosed |
| US-20070135396-A1 | 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations | WYETH (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070135397-A1 | 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations | WYETH (US) | 2007-06-14 | — | — | US | disclosed |
| US-20070054895-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | WYETH (US) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329784-A1 | 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLE AND ESTROGEN FORMULATIONS | ESR2, ESR1, CYP19A1 | NR1I2 197/4885CTSV 3372/4885CTSL 4392/4885 |
| US-20120330008-A1 | NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | CYP19A1, HSD17B11, SULT1E1 | NR1I2 513/4885CTSV 4601/4885CTSL 4526/4885 |
| US-20120252769-A1 | 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLE AND ESTROGEN FORMULATIONS | ESR2, ESR1, CYP19A1 | NR1I2 197/4885CTSV 3372/4885CTSL 4392/4885 |
| US-20070135397-A1 | 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations | ESR2, ESR1, CYP19A1 | NR1I2 197/4885CTSV 3372/4885CTSL 4392/4885 |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | PSMA6, PSMC1, PSMA1 | NR1I2 2617/4885CTSV 232/4885CTSL 283/4885 |
| US-20070135396-A1 | 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole and estrogen formulations | ESR2, ESR1, CYP19A1 | NR1I2 197/4885CTSV 3372/4885CTSL 4392/4885 |
| US-20130289296-A1 | NOVEL PROCESS FOR THE PREPARATION OF BAZEDOXIFENE ACETATE AND INTERMEDIATES THEREOF | CYP19A1, HSD17B11, SULT1E1 | NR1I2 513/4885CTSV 4601/4885CTSL 4526/4885 |
| US-20070142361-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations | ESR1, ESR2, CYP19A1 | NR1I2 185/4885CTSV 3411/4885CTSL 4433/4885 |
| US-20090176764-A1 | 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLES AS ESTROGENIC AGENTS | BRCA1, ESR2, PKD2 | NR1I2 987/4885CTSV 1933/4885CTSL 1407/4885 |
| US-20080021017-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | BRCA1, PKD2, CYP19A1 | NR1I2 1260/4885CTSV 1958/4885CTSL 1244/4885 |
| US-20070054895-A1 | 2-Phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents | ESR2, GPER1, ESR1 | NR1I2 125/4885CTSV 4702/4885CTSL 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.