Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.56 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.49 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29058721 | 0.94 | ALOX5AP (0.51) | GPR119ALOX5APFEN1SLC2A1 | |
| SCHEMBL29058742 | 0.89 | ALOX5AP (0.47) | GPR119ALOX5APFEN1 | |
| SCHEMBL29913159 | 0.85 | GPR119 (0.56) | GPR119ALOX5APFEN1SLC2A1FAAH | |
| SCHEMBL27158327 | 0.85 | GPR119 (0.56) | GPR119ALOX5APFEN1SLC2A1FAAH | |
| SCHEMBL1475349 | 0.84 | KDM4E (0.54) | GPR119ALOX5APFEN1KDM4EPKM | |
| SCHEMBL17136330 | 0.83 | GPR119 (0.52) | GPR119ALOX5APFEN1SLC2A1FAAH | |
| SCHEMBL18860082 | 0.83 | KDM1A (0.55) | GPR119 | |
| SCHEMBL27158155 | 0.83 | GPR119 (0.56) | GPR119ALOX5APFEN1SLC2A1FAAH | |
| SCHEMBL30785480 | 0.83 | GPR119 (0.56) | GPR119ALOX5APFEN1SLC2A1FAAH | |
| SCHEMBL4665126 | 0.82 | GPR119 (0.52) | GPR119ALOX5APFEN1FAAHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478152-A | Small molecular marrow cell proliferation inhibitor and preparation method and application thereof | 复旦大学 | 2023-07-25 | — | — | CN | disclosed |
| US-10174002-B2 | Pyridine derivatives as CFTR modulators | NuBridge BioSciences (US) | 2019-01-08 | — | — | US | disclosed |
| US-10174002-B2 | Pyridine derivatives as CFTR modulators | NuBridge BioSciences (US) | 2019-01-08 | — | — | US | disclosed |
| US-20170101394-A1 | PYRIDINE DERIVATIVES AS CFTR MODULATORS | NuBridge BioSciences | 2017-04-13 | — | — | US | disclosed |
| US-20170101394-A1 | PYRIDINE DERIVATIVES AS CFTR MODULATORS | NuBridge BioSciences | 2017-04-13 | — | — | US | disclosed |
| US-20170101394-A1 | PYRIDINE DERIVATIVES AS CFTR MODULATORS | NuBridge BioSciences | 2017-04-13 | — | — | US | disclosed |
| WO-2017045615-A1 | PYRIDINE DERIVATIVE PIM KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN MEDICINE PREPARATION | 上海吉铠医药科技有限公司 | 2017-03-23 | — | — | WO | disclosed |
| US-9452995-B2 | Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof | Jikai Biosciences, Inc. (CN) | 2016-09-27 | — | — | US | disclosed |
| US-9452995-B2 | Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof | Jikai Biosciences, Inc. (CN) | 2016-09-27 | — | — | US | disclosed |
| US-9452995-B2 | Pyridine derivatives as PIM kinase inhibitors and preparation methods and use in medicinal manufacture thereof | Jikai Biosciences, Inc. (CN) | 2016-09-27 | — | — | US | disclosed |
| US-20150284363-A1 | PYRIDINE DERIVATIVES AS PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences, Inc. | 2015-10-08 | — | — | US | disclosed |
| US-20150284363-A1 | PYRIDINE DERIVATIVES AS PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences, Inc. | 2015-10-08 | — | — | US | disclosed |
| US-20150284363-A1 | PYRIDINE DERIVATIVES AS PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | Jikai Biosciences, Inc. | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174002-B2 | Pyridine derivatives as CFTR modulators | CFTR, SCNN1B, SLC26A4 | GPR119 395/4885ALOX5AP 2521/4885FEN1 3801/4885 |
| US-20150284363-A1 | PYRIDINE DERIVATIVES AS PIM KINASE INHIBITORS AND PREPARATION METHODS AND USE IN MEDICINAL MANUFACTURE THEREOF | PIM1, PIM2, PIM3 | GPR119 1604/4885ALOX5AP 3544/4885FEN1 3164/4885 |
| US-20170101394-A1 | PYRIDINE DERIVATIVES AS CFTR MODULATORS | CFTR, SCNN1B, SLC26A4 | GPR119 510/4885ALOX5AP 2481/4885FEN1 3610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.