Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 9/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.49 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21904166 | 0.87 | OPRL1 (0.44) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL16618534 | 0.84 | OPRL1 (0.49) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL31559318 | 0.81 | OPRK1 (0.46) | OPRM1OPRL1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL2488961 | 0.81 | OPRL1 (0.48) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL12782404 | 0.79 | OPRL1 (0.63) | OPRM1OPRL1OPRK1OPRD1IP6K1 | |
| SCHEMBL31330332 | 0.78 | OPRK1 (0.46) | OPRM1OPRL1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL2144650 | 0.77 | MEN1 (0.40) | OPRM1OPRL1OPRK1OPRD1CYP19A1 | |
| SCHEMBL30411919 | 0.77 | OPRL1 (0.60) | OPRM1OPRL1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL15579138 | 0.77 | OPRL1 (0.60) | OPRM1OPRL1OPRK1OPRD1ALDH1A1 | |
| SCHEMBL31251176 | 0.77 | MEN1 (0.40) | OPRM1OPRL1OPRK1OPRD1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895476-B1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-9221816-B2 | 2-oxo-2,3-dihydro-indoles for the treatment of CNS disorders | HOFFMANN LA-ROCHE INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20150284386-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284386-A1 | 2-OXO-2,3-DIHYDRO-INDOLES FOR THE TREATMENT OF CNS DISORDERS | HCRTR2, TPH2, CNR2 | OPRM1 32/4885OPRL1 45/4885OPRK1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.