Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 15/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118148 | 0.82 | PARP1 (0.52) | PARP1ADORA1CSF1R | |
| SCHEMBL14792981 | 0.82 | PARP1 (0.52) | PARP1ADORA1CSF1RLOXL2 | |
| SCHEMBL171414 | 0.82 | LOXL2 (0.53) | PARP1ADORA1CSF1RLOXL2 | |
| SCHEMBL17546406 | 0.81 | LRRK2 (0.48) | ADORA1 | |
| SCHEMBL169192 | 0.81 | KMT2A (0.54) | PARP1CSF1RLOXL2 | |
| SCHEMBL19448543 | 0.78 | BRD4 (0.51) | SAE1UBA2LOXL2 | |
| SCHEMBL13603764 | 0.77 | KDR (0.62) | CSF1R | |
| Hydrochloric Acid SCHEMBL244555 | 0.77 | PARP1 (0.49) | PARP1ADORA1CSF1RLOXL2 | |
| SCHEMBL30542691 | 0.76 | PARP1 (0.51) | PARP1ADORA1CSF1RLOXL2 | |
| SCHEMBL246824 | 0.76 | PARP1 (0.51) | PARP1ADORA1CSF1RLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |