Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20118148 | 0.84 | PARP1 (0.52) | PARP1CSF1RTSHRMAPK14BRAF | |
| SCHEMBL14792981 | 0.84 | PARP1 (0.52) | PARP1CSF1RTSHRKDRLOXL2 | |
| SCHEMBL171414 | 0.84 | LOXL2 (0.53) | PARP1CSF1RBRD4KDRLOXL2 | |
| SCHEMBL12020808 | 0.83 | RAB9A (0.49) | KMT2APARP1CSF1RPLK1 | |
| SCHEMBL171424 | 0.81 | PARP1 (0.49) | PARP1CSF1RLOXL2 | |
| SCHEMBL246824 | 0.79 | PARP1 (0.51) | PARP1CSF1RBRAFKDRLOXL2 | |
| SCHEMBL18922125 | 0.79 | SMYD3 (0.58) | PARP1CSF1RPLK1BRAFKDR | |
| SCHEMBL30542691 | 0.79 | PARP1 (0.51) | PARP1CSF1RBRAFKDRLOXL2 | |
| SCHEMBL2642933 | 0.77 | LOXL2 (0.62) | PARP1KDRLOXL2SMYD3 | |
| SCHEMBL14354793 | 0.77 | PARP1 (0.50) | PARP1CSF1RBRAFKDRLOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |