Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 10/20 | 0.44 |
| ▸ | KDM4A | O75164 | 5/20 | 0.44 |
| ▸ | KDM5C | P41229 | 5/20 | 0.44 |
| ▸ | KDM4B | O94953 | 2/20 | 0.44 |
| ▸ | KDM5A | P29375 | 4/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17144655 | 1.00 | KDM5B (0.44) | KDM5BKDM4AKDM5CKDM4BKDM5A | |
| SCHEMBL17683817 | 0.71 | ALDH1A1 (0.34) | TBXAS1SMN1; SMN2 | |
| SCHEMBL17549930 | 0.69 | MEN1 (0.32) | KDM5BKDM4AKDM5CKDM5AKDM2B | |
| SCHEMBL15639200 | 0.68 | HDAC6 (0.51) | KDM5BKDM4AKDM5CKDM4BKDM5A | |
| SCHEMBL15637011 | 0.68 | KDM5B (0.77) | KDM5BKDM4AKDM5CKDM4BKDM5A | |
| SCHEMBL17670491 | 0.67 | HDAC1 (0.35) | PPARGPPARA | |
| SCHEMBL17670494 | 0.67 | HDAC1 (0.35) | PPARGPPARA | |
| SCHEMBL7359022 | 0.67 | OPRD1 (0.45) | OPRD1TBXAS1MCHR1PPARGPPARA | |
| SCHEMBL17670496 | 0.67 | ALDH1A1 (0.40) | KDM5BKDM4AKDM5CKDM4BKDM5A | |
| SCHEMBL17144440 | 0.65 | KDM5B (0.49) | KDM5BKDM4AKDM5CKDM4BKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126345-A1 | INHIBITORS OF HISTONE DEMETHYLASES | Gilead Sciences, Inc. (US) | 2017-02-08 | — | — | EP | claimed |
| WO-2015153498-A1 | INHIBITORS OF HISTONE DEMETHYLASES | EPITHERAPEUTICS, APS (DK) | 2015-10-08 | — | — | WO | claimed |