Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 18/20 | 0.40 |
| ▸ | UBA3 | Q8TBC4 | 18/20 | 0.40 |
| ▸ | SAE1 | Q9UBE0 | 14/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 14/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | UBA1 | P22314 | 1/20 | 0.31 |
| ▸ | UBE2E1 | P51965 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL802482 | 0.87 | NAE1 (0.52) | NAE1UBA3SAE1UBA2CA1 | |
| SCHEMBL18538005 | 0.87 | NAE1 (0.52) | NAE1UBA3SAE1UBA2CA1 | |
| SCHEMBL802365 | 0.78 | UBA1 (0.48) | NAE1UBA3SAE1UBA2UBA1 | |
| SCHEMBL802424 | 0.77 | CHRM3 (0.32) | — | |
| SCHEMBL803312 | 0.77 | NAE1 (0.42) | NAE1UBA3SAE1UBA2CA1 | |
| SCHEMBL803001 | 0.74 | ATG7 (0.38) | NAE1UBA3 | |
| SCHEMBL802964 | 0.74 | CA2 (0.39) | NAE1UBA3CA1CA2UBA1 | |
| SCHEMBL802373 | 0.67 | NAE1 (0.35) | NAE1UBA3 | |
| SCHEMBL802500 | 0.67 | NAE1 (0.35) | NAE1UBA3 | |
| SCHEMBL803339 | 0.65 | PDE10A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150525-B2 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |