Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
| ▸ | HPGDS | O60760 | 2/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 5/20 | 0.46 |
| ▸ | ALPL | P05186 | 2/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21409312 | 0.86 | ATM (0.45) | HPGDSMKNK1MKNK2CSNK1EATM | |
| SCHEMBL23018208 | 0.84 | MKNK1 (0.49) | MKNK1MKNK2CSNK1ENTRK1ATM | |
| SCHEMBL18246429 | 0.84 | KDM4E (0.57) | MKNK1MKNK2CSNK1EATMTAS2R8 | |
| SCHEMBL5909485 | 0.82 | RAF1 (0.53) | PLK1HPGDSMKNK1MKNK2RAF1 | |
| SCHEMBL1439962 | 0.81 | ATM (0.65) | MKNK1MKNK2ALPLATMHPGD | |
| SCHEMBL29224909 | 0.81 | RAF1 (0.46) | PLK1HPGDSMKNK1MKNK2RAF1 | |
| SCHEMBL12923938 | 0.81 | MKNK1 (0.53) | HPGDSMKNK1MKNK2RAF1SMN1; SMN2 | |
| SCHEMBL21409268 | 0.80 | ALDH1A1 (0.41) | MKNK1MKNK2CSNK1ETSHRSMN1; SMN2 | |
| SCHEMBL3209723 | 0.79 | CYP11B1 (0.58) | MKNK1MKNK2ATM | |
| SCHEMBL30240892 | 0.79 | HCAR2 (0.57) | MKNK1MKNK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9149465-B2 | Isoxazolines as inhibitors of fatty acid amide hydrolase | INFINITY PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |