Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | BCHE | P06276 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11583950 | 0.93 | KCNH2 (0.47) | KCNH2BCHEDRD2OPRM1DRD3 | |
| SCHEMBL10991921 | 0.93 | KCNH2 (0.47) | KCNH2BCHEDRD2OPRM1DRD3 | |
| SCHEMBL13060688 | 0.89 | CALM1 (0.48) | CALM1CAMKK2KCNH2BCHEDRD2 | |
| SCHEMBL7130458 | 0.85 | KCNH2 (0.54) | KCNH2BCHEDRD2OPRM1DRD3 | |
| SCHEMBL13005598 | 0.84 | CALM1 (0.44) | CALM1CAMKK2KCNH2BCHEDRD2 | |
| SCHEMBL24899621 | 0.82 | CALM1 (0.46) | CALM1CAMKK2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL13060649 | 0.81 | KCNH2 (0.54) | CALM1CAMKK2KCNH2BCHEDRD2 | |
| SCHEMBL10993324 | 0.80 | MAPT (0.62) | KCNH2MAPT | |
| SCHEMBL7766004 | 0.79 | KCNH2 (0.60) | KCNH2BCHEDRD2OPRM1DRD3 | |
| SCHEMBL8722891 | 0.79 | KCNH2 (0.60) | KCNH2BCHEDRD2OPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |