Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 10/20 | 0.69 |
| ▸ | EBP | Q15125 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | LSS | P48449 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004280 | 0.93 | ESR1 (0.70) | ESR1ESR2EBPSIGMAR1LTA4H | |
| SCHEMBL6756238 | 0.91 | ESR1 (0.80) | ESR1ESR2EBPSIGMAR1LSS | |
| SCHEMBL6756246 | 0.85 | ESR1 (0.72) | ESR1ESR2EBPSIGMAR1LSS | |
| SCHEMBL13350201 | 0.84 | ESR1 (0.71) | ESR1ESR2EBPSIGMAR1 | |
| SCHEMBL8004295 | 0.81 | ESR1 (0.55) | ESR1ESR2EBPSIGMAR1LTA4H | |
| SCHEMBL11187322 | 0.80 | ESR1 (0.55) | ESR1ESR2EBPSIGMAR1LTA4H | |
| SCHEMBL5732868 | 0.79 | ESR1 (0.62) | ESR1ESR2EBPSIGMAR1LSS | |
| SCHEMBL6756233 | 0.79 | ESR1 (0.68) | ESR1ESR2EBPSIGMAR1LTA4H | |
| SCHEMBL5732864 | 0.79 | ESR1 (0.62) | ESR1ESR2EBPSIGMAR1LSS | |
| SCHEMBL8004275 | 0.78 | ESR1 (0.54) | ESR1ESR2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687458-B2 | Trans-clomiphene for use in cancer therapy | REPROS THERAPEUTICS INC. (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150283099-A1 | Trans-Clomiphene for Use in Cancer Therapy | REPROS THERAPEUTICS INC. (US) | 2015-10-08 | — | — | US | disclosed |