Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | YEATS4 | O95619 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 4/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15627982 | 1.00 | APLNR (0.55) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL17152618 | 0.93 | APLNR (0.51) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL15627765 | 0.93 | APLNR (0.51) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL18433104 | 0.91 | APLNR (0.48) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL17152656 | 0.90 | APLNR (0.51) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL15627902 | 0.90 | APLNR (0.51) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL18432894 | 0.88 | APLNR (0.56) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL15627769 | 0.88 | APLNR (0.56) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL15627768 | 0.88 | APLNR (0.56) | APLNRNPC1ALDH1A1LMNAHPGD | |
| SCHEMBL17152354 | 0.88 | APLNR (0.56) | APLNRNPC1ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | claimed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | claimed |
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |