Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 5/20 | 0.40 |
| ▸ | BRAF | P15056 | 5/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715873 | 0.90 | CCNE1 (0.38) | MAPK10MAPK8KITBRAFCDK5 | |
| SCHEMBL1715490 | 0.84 | KIT (0.44) | KITBRAFHSD17B10ALDH1A1 | |
| SCHEMBL1715329 | 0.83 | KIT (0.40) | PIK3C3KITBRAFKDM4E | |
| SCHEMBL1715861 | 0.82 | KIT (0.42) | KITBRAF | |
| SCHEMBL1715531 | 0.82 | AURKA (0.47) | MAPK10KITBRAFTSHR | |
| SCHEMBL1715659 | 0.81 | KIT (0.45) | KITBRAFCDK5DYRK1ACDK5R1 | |
| SCHEMBL1715094 | 0.81 | KIT (0.49) | PIK3C3KITBRAF | |
| SCHEMBL1715456 | 0.79 | KIT (0.40) | KITBRAF | |
| SCHEMBL1715686 | 0.79 | KDM4E (0.44) | KITBRAFCDK5DYRK1ACDK5R1 | |
| SCHEMBL1714842 | 0.79 | KIT (0.41) | KITBRAFCDK5DYRK1ACDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034811-B2 | Hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA A/S (DK) | 2011-10-11 | — | — | US | claimed |
| EP-1697312-B1 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2011-07-20 | — | — | EP | claimed |
| US-8034811-B2 | Hydroxamic acid esters and pharmaceutical use thereof | LEO PHARMA A/S (DK) | 2011-10-11 | — | — | US | disclosed |
| EP-1697312-B1 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2011-07-20 | — | — | EP | disclosed |