Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 9/20 | 0.38 |
| ▸ | BRAF | P15056 | 9/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715290 | 0.90 | MAPK10 (0.49) | KITBRAFMAPK8MAPK10CDK5 | |
| SCHEMBL1715456 | 0.84 | KIT (0.40) | KITBRAFADRA1A | |
| SCHEMBL1715490 | 0.82 | KIT (0.44) | KITBRAFL3MBTL1 | |
| SCHEMBL1716061 | 0.82 | AURKA (0.37) | KITBRAFCDK5CDK5R1DYRK1A | |
| SCHEMBL1715861 | 0.80 | KIT (0.42) | KITBRAF | |
| SCHEMBL1715659 | 0.80 | KIT (0.45) | KITBRAFCDK5CDK5R1DYRK1A | |
| SCHEMBL1715094 | 0.79 | KIT (0.49) | KITBRAFADRA1A | |
| SCHEMBL1715329 | 0.78 | KIT (0.40) | KITBRAFADRA1A | |
| SCHEMBL1715531 | 0.77 | AURKA (0.47) | KITBRAFMAPK10L3MBTL1 | |
| SCHEMBL1715686 | 0.77 | KDM4E (0.44) | KITBRAFCDK5CDK5R1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697312-B1 | HYDROXAMIC ACID ESTERS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2011-07-20 | — | — | EP | claimed |