Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 2/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | PRKCB | P05771 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | PRKCH | P24723 | 1/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.49 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 5/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18412555 | 0.93 | EGFR (0.54) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL17153269 | 0.92 | EGFR (0.59) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL18412553 | 0.88 | PRKCA (0.46) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL17153051 | 0.86 | EGFR (0.47) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL17153131 | 0.83 | ABL1 (0.47) | PRKCAPRKCDEGFRABL1SRC | |
| SCHEMBL17153153 | 0.83 | PRKCA (0.42) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL17152843 | 0.83 | PRKCA (0.42) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL17153274 | 0.81 | PRKCA (0.42) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL18412554 | 0.81 | PRKCA (0.42) | PRKCAPRKCDPRKD3EGFRPRKCG | |
| SCHEMBL17153041 | 0.80 | CDK19 (0.41) | PRKCAPRKCDABL1SRCBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015150555-A1 | MACROCYLIC PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-08 | — | — | WO | disclosed |