Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKCG | P05129 | 1/20 | 0.59 |
| ▸ | PRKCB | P05771 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | PRKCA | P17252 | 1/20 | 0.59 |
| ▸ | PRKCH | P24723 | 1/20 | 0.59 |
| ▸ | PRKCI | P41743 | 1/20 | 0.59 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.59 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.59 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.59 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.59 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 6/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18412555 | 0.96 | EGFR (0.54) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL17153140 | 0.92 | PRKCA (0.49) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL17153051 | 0.88 | EGFR (0.47) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL18412553 | 0.86 | PRKCA (0.46) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL17155072 | 0.85 | CSNK2A1 (0.40) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL17153131 | 0.85 | ABL1 (0.47) | EGFRPRKCAPRKCDCSNK2A1CAMK2D | |
| SCHEMBL17153274 | 0.84 | PRKCA (0.42) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL17153153 | 0.83 | PRKCA (0.42) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL18412554 | 0.82 | PRKCA (0.42) | EGFRPRKD3PRKCGPRKCBLCK | |
| SCHEMBL17152843 | 0.81 | PRKCA (0.42) | EGFRPRKD3PRKCGPRKCBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017509-B2 | Macrocylic pyrimidine derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2018-07-10 | — | — | US | disclosed |
| US-20170022202-A1 | MACROCYLIC PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-01-26 | — | — | US | disclosed |
| WO-2015150555-A1 | MACROCYLIC PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170022202-A1 | MACROCYLIC PYRIMIDINE DERIVATIVES | EEF2K, VPS26B, VPS28 | EGFR 3903/4885PRKD3 1378/4885PRKCG 2622/4885 |
| US-10017509-B2 | Macrocylic pyrimidine derivatives | EEF2K, VPS26B, VPS28 | EGFR 3903/4885PRKD3 1378/4885PRKCG 2622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.