Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156161 | 0.83 | DHODH (0.50) | L3MBTL1LMNAMEN1KMT2AMAPT | |
| SCHEMBL17156291 | 0.83 | MAPT (0.44) | L3MBTL1LMNAMEN1KMT2AMAPT | |
| SCHEMBL17156142 | 0.83 | MRGPRX1 (0.42) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL17156216 | 0.81 | TTR (0.42) | TTRLMNAMEN1KMT2AMAPT | |
| SCHEMBL3260000 | 0.80 | KMT2A (0.48) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL17156183 | 0.78 | CCR4 (0.41) | TTRL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL17156374 | 0.77 | TTR (0.46) | TTRLMNAMEN1KMT2AMAPT | |
| SCHEMBL17156249 | 0.73 | LPAR2 (0.41) | LMNAMEN1KMT2AMAPTTP53 | |
| SCHEMBL17156158 | 0.71 | MAPT (0.46) | L3MBTL1LMNAMEN1KMT2AMAPT | |
| SCHEMBL3392191 | 0.71 | MEN1 (0.45) | LMNAMEN1KMT2AMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |