Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156325 | 0.83 | TTR (0.48) | MRGPRX1KMT2AMEN1LMNATP53 | |
| SCHEMBL17156291 | 0.80 | MAPT (0.44) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL17156161 | 0.80 | DHODH (0.50) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL3260000 | 0.76 | KMT2A (0.48) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL17156158 | 0.76 | MAPT (0.46) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL17156183 | 0.75 | CCR4 (0.41) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL17156146 | 0.75 | L3MBTL1 (0.47) | KMT2AMEN1LMNATP53MAPT | |
| SCHEMBL31035275 | 0.72 | ALDH1A1 (0.50) | KMT2AMAPTNPSR1TRPA1HPGD | |
| SCHEMBL6946500 | 0.72 | ALDH1A1 (0.50) | KMT2AMAPTNPSR1TRPA1HPGD | |
| SCHEMBL17156249 | 0.70 | LPAR2 (0.41) | KMT2AMEN1LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |