Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | CLPP | Q16740 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391586 | 0.92 | C5AR1 (0.43) | HTTMAPTNPC1RAB9AC5AR1 | |
| SCHEMBL3390126 | 0.77 | CLPP (0.45) | C5AR1CLPPDRD2DRD4DRD3 | |
| SCHEMBL23648628 | 0.75 | C5AR1 (0.46) | HTTMAPTNPC1RAB9AC5AR1 | |
| SCHEMBL29871610 | 0.75 | C5AR1 (0.46) | HTTMAPTNPC1RAB9AC5AR1 | |
| SCHEMBL3390729 | 0.74 | CLPP (0.46) | C5AR1CLPPDRD2DRD4DRD3 | |
| SCHEMBL3390016 | 0.74 | CLPP (0.45) | C5AR1CLPPDRD2DRD4DRD3 | |
| SCHEMBL29871084 | 0.73 | MAPT (0.44) | HTTMAPTNPC1RAB9ALMNA | |
| SCHEMBL23648607 | 0.73 | MAPT (0.44) | HTTMAPTNPC1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL23648819 | 0.73 | MAPT (0.43) | HTTMAPTNPC1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL29871578 | 0.73 | MAPT (0.43) | HTTMAPTNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |