Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156521 | 0.81 | HTR7 (0.51) | CYP3A4CYP2D6HRH4HTR7 | |
| SCHEMBL20611944 | 0.77 | HTR7 (0.54) | CYP3A4CYP2D6HRH4ROCK2ROCK1 | |
| SCHEMBL31461321 | 0.74 | HTR7 (0.64) | PRKCILMNANTSR1HTR7 | |
| SCHEMBL853076 | 0.73 | NOTUM (0.58) | PRKCIDRD3KCNH2NTSR1BRPF1 | |
| SCHEMBL13598508 | 0.71 | PRKCI (0.52) | PRKCINTSR1BRPF1TSHROXER1 | |
| SCHEMBL4959132 | 0.71 | PRKCI (0.52) | CYP3A4PRKCINTSR1BRPF1POLB | |
| SCHEMBL15784118 | 0.70 | DRD4 (0.55) | POLB | |
| SCHEMBL20611946 | 0.70 | ROCK1 (0.42) | CYP3A4CYP2D6ROCK2ROCK1LMNA | |
| SCHEMBL7483288 | 0.70 | PRKCI (0.47) | CYP3A4PRKCILMNANTSR1BRPF1 | |
| SCHEMBL16897912 | 0.69 | ALDH1A1 (0.47) | CYP3A4CYP2D6DRD3KCNH2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2930167-B1 | AN INDOLINONE DERIVATIVE AS TYROSINE KINASE INHIBITOR | KBP BIOSCIENCES CO LTD (CN) | 2018-11-21 | — | — | EP | disclosed |
| US-9642851-B2 | Indolinone derivative as tyrosine kinase inhibitor | KBP BIOSCIENCES CO., LTD. (CN) | 2017-05-09 | — | — | US | disclosed |
| US-20150306095-A1 | An Indolinone Derivative As Tyrosine Kinase Inhibitor | KBP BIOSCIENCES CO., LTD. (CN) | 2015-10-29 | — | — | US | disclosed |
| EP-2930167-A1 | INDOLE FULL KETONE DERIVATIVE USED AS TYROSINE-KINASE INHIBITOR | KBP Biosciences Co., Ltd. (CN) | 2015-10-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150306095-A1 | An Indolinone Derivative As Tyrosine Kinase Inhibitor | FRK, LRRK2, TNNI3K | CYP3A4 2932/4885CYP2D6 2207/4885PRKCI 1154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.