Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17157145 | 1.00 | KMT2A (0.43) | KMT2AMEN1CA2SMN1; SMN2NPC1 | |
| SCHEMBL23459129 | 0.86 | KMT2A (0.42) | KMT2ANPC1RAB9A | |
| SCHEMBL23459130 | 0.86 | KMT2A (0.42) | KMT2ANPC1RAB9A | |
| SCHEMBL17174237 | 0.86 | PPARG (0.49) | SMN1; SMN2NPC1RAB9AMAPTPPARG | |
| SCHEMBL22154610 | 0.86 | PPARG (0.49) | SMN1; SMN2NPC1RAB9AMAPTPPARG | |
| SCHEMBL22121189 | 0.83 | MEN1 (0.42) | KMT2AMEN1LMNAMAPTPPARG | |
| SCHEMBL17171322 | 0.82 | SMN1; SMN2 (0.43) | KMT2AMEN1SMN1; SMN2NPC1TP53 | |
| SCHEMBL17748796 | 0.81 | MEN1 (0.46) | KMT2AMEN1CA2SMN1; SMN2NPC1 | |
| SCHEMBL17157170 | 0.80 | LMNA (0.46) | KMT2AMEN1CA2SMN1; SMN2NPC1 | |
| SCHEMBL17157166 | 0.80 | LMNA (0.46) | KMT2AMEN1CA2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10159745-B2 | Tubulysin derivatives | MEDIMMUNE, LLC (US) | 2018-12-25 | — | — | US | disclosed |
| EP-3129362-A1 | TUBULYSIN DERIVATIVES | Medimmune, LLC (US) | 2017-02-15 | — | — | EP | disclosed |
| US-20160339114-A1 | TUBULYSIN DERIVATIVES | MEDIMMUNE LLC (US) | 2016-11-24 | — | — | US | disclosed |
| US-9427479-B2 | Tubulysin derivatives | MEDIMMUNE LLC (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150291657-A1 | TUBULYSIN DERIVATIVES | MEDIMMUNE LLC (US) | 2015-10-15 | — | — | US | disclosed |
| WO-2015157594-A1 | TUBULYSIN DERIVATIVES | MEDIMMUNE LLC (US) | 2015-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10159745-B2 | Tubulysin derivatives | TEKT1, TWF2, TEK | KMT2A 2974/4885MEN1 1060/4885CA2 2254/4885 |
| US-20150291657-A1 | TUBULYSIN DERIVATIVES | TEKT1, TWF2, TEK | KMT2A 2974/4885MEN1 1060/4885CA2 2254/4885 |
| US-20160339114-A1 | TUBULYSIN DERIVATIVES | TEKT1, TWF2, TEK | KMT2A 2974/4885MEN1 1060/4885CA2 2254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.