Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17157145 | 0.81 | KMT2A (0.43) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL17157142 | 0.81 | KMT2A (0.43) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL17728782 | 0.76 | MEN1 (0.39) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL17728779 | 0.76 | MEN1 (0.39) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL17157185 | 0.76 | LMNA (0.47) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL17157182 | 0.76 | LMNA (0.47) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL18444555 | 0.75 | CA2 (0.54) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL20454423 | 0.75 | CA2 (0.54) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL17157170 | 0.74 | LMNA (0.46) | MEN1KMT2ANPC1TP53RAB9A | |
| SCHEMBL17157166 | 0.74 | LMNA (0.46) | MEN1KMT2ANPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218391-B1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | BRISTOL MYERS SQUIBB CO (US) | 2019-01-09 | — | — | EP | disclosed |
| EP-3218391-A1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | Bristol-Myers Squibb Company (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077260-A1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-05-19 | — | — | WO | disclosed |