Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17164357 | 0.96 | CHRNB4 (0.37) | S1PR4CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL21854579 | 0.95 | MAPT (0.37) | S1PR4CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL18738841 | 0.88 | CNR1 (0.31) | — | |
| SCHEMBL18703334 | 0.86 | MAPT (0.43) | S1PR4CHRNB2CHRNA4MEN1KMT2A | |
| SCHEMBL20448215 | 0.84 | MAPT (0.38) | S1PR4CHRNB2CHRNA4MEN1KMT2A | |
| SCHEMBL18738859 | 0.84 | CNR1 (0.32) | — | |
| SCHEMBL20522004 | 0.84 | MAPT (0.39) | MEN1KMT2AL3MBTL1LMNAMAPT | |
| SCHEMBL28108700 | 0.84 | PPARA (0.42) | MEN1KMT2AL3MBTL1LMNAMAPT | |
| SCHEMBL20521493 | 0.83 | MAPT (0.37) | S1PR4CHRNB2CHRNA4KCNH2LMNA | |
| SCHEMBL17164338 | 0.82 | MAPT (0.43) | MEN1KMT2AL3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691986-B2 | PTEFB inhibiting macrocyclic compounds | BAYER AKTIENGESELLSCHAFT (DE) | 2023-07-04 | — | — | US | disclosed |
| US-20220281892-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-09-08 | — | — | US | disclosed |
| US-20220267353-A1 | PTEFB INHIBITING MACROCYCLIC COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2022-08-25 | — | — | US | disclosed |
| US-11254690-B2 | PTEFb inhibiting macrocyclic compounds | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2022-02-22 | — | — | US | disclosed |
| US-11242356-B2 | PTEFb inhibiting macrocyclic compounds | BAYER AKTIENGESELLSCHAFT (DE) | 2022-02-08 | — | — | US | disclosed |
| EP-3601253-B1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | BAYER AG (DE) | 2021-09-15 | — | — | EP | disclosed |
| US-20200347079-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-11-05 | — | — | US | disclosed |
| US-20200123174-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-04-23 | — | — | US | disclosed |
| EP-3601236-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | Bayer Aktiengesellschaft (DE) | 2020-02-05 | — | — | EP | disclosed |
| EP-3601253-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | Bayer Aktiengesellschaft (DE) | 2020-02-05 | — | — | EP | disclosed |
| WO-2018177899-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2018-10-04 | — | — | WO | disclosed |
| WO-2018177889-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2018-10-04 | — | — | WO | disclosed |
| US-9963464-B2 | Macrocyclic compounds | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-08 | — | — | US | disclosed |
| WO-2017060322-A2 | PTEFB-INHIBITOR-ADC | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-13 | — | — | WO | disclosed |
| WO-2017060322-A2 | PTEFB-INHIBITOR-ADC | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-13 | — | — | WO | disclosed |
| EP-3129387-A1 | NOVEL MACROCYCLIC COMPOUNDS | Bayer Pharma Aktiengesellschaft (DE) | 2017-02-15 | — | — | EP | disclosed |
| US-20170029439-A1 | NOVEL MACROCYCLIC COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-02-02 | — | — | US | disclosed |
| US-20170029439-A1 | NOVEL MACROCYCLIC COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-02-02 | — | — | US | disclosed |
| WO-2015155197-A1 | NOVEL MACROCYCLIC COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-15 | — | — | WO | disclosed |
| WO-2015155197-A1 | NOVEL MACROCYCLIC COMPOUNDS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029439-A1 | NOVEL MACROCYCLIC COMPOUNDS | PCNA, CCNI, PKD1 | S1PR4 3767/4885CHRNB2 4863/4885CHRNA4 4884/4885 |
| US-11242356-B2 | PTEFb inhibiting macrocyclic compounds | PCLAF, PPIB, RHEB | S1PR4 3456/4885CHRNB2 4858/4885CHRNA4 4885/4885 |
| US-20220281892-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | PCLAF, PKD1, RHEB | S1PR4 3819/4885CHRNB2 4849/4885CHRNA4 4884/4885 |
| US-20200347079-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | PCLAF, PKD1, RHEB | S1PR4 3819/4885CHRNB2 4849/4885CHRNA4 4884/4885 |
| US-11254690-B2 | PTEFb inhibiting macrocyclic compounds | PCLAF, PPIB, RHEB | S1PR4 3456/4885CHRNB2 4858/4885CHRNA4 4885/4885 |
| US-20200123174-A1 | NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS | PCLAF, PKD1, RHEB | S1PR4 3819/4885CHRNB2 4849/4885CHRNA4 4884/4885 |
| US-11691986-B2 | PTEFB inhibiting macrocyclic compounds | PCLAF, PPIB, RHEB | S1PR4 3456/4885CHRNB2 4858/4885CHRNA4 4885/4885 |
| US-20220267353-A1 | PTEFB INHIBITING MACROCYCLIC COMPOUNDS | PCLAF, PPIB, RHEB | S1PR4 3456/4885CHRNB2 4858/4885CHRNA4 4885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.