Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17164367 | 0.86 | S1PR4 (0.38) | MAPTMEN1KMT2AS1PR4ALOX5 | |
| SCHEMBL17164357 | 0.85 | CHRNB4 (0.37) | MAPTMEN1KMT2AS1PR4ALOX5 | |
| SCHEMBL21854579 | 0.84 | MAPT (0.37) | MAPTMEN1KMT2AS1PR4ALOX5 | |
| SCHEMBL20448215 | 0.84 | MAPT (0.38) | MAPTMEN1KMT2ARAB9AS1PR4 | |
| SCHEMBL15719607 | 0.83 | LMNA (0.44) | MAPTMEN1KMT2AMAPK1ALOX5 | |
| SCHEMBL20521493 | 0.83 | MAPT (0.37) | MAPTRAB9AS1PR4CHRNB2CHRNA4 | |
| SCHEMBL16953815 | 0.82 | MAPT (0.44) | MAPTMEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL6586321 | 0.82 | MAPT (0.44) | MAPTMEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL17164338 | 0.81 | MAPT (0.43) | MAPTMEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL20522004 | 0.81 | MAPT (0.39) | MAPTMEN1KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017060322-A2 | PTEFB-INHIBITOR-ADC | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-13 | — | — | WO | disclosed |