Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11601220 | 0.83 | ENPP2 (0.48) | ENPP2GSK3BGRM4TNFTSHR | |
| SCHEMBL4693798 | 0.83 | ENPP2 (0.48) | ENPP2GSK3BGRM4TNFTSHR | |
| SCHEMBL30583447 | 0.80 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL29857813 | 0.80 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL27948985 | 0.80 | GSK3B (0.51) | ENPP2GSK3BGRM4TNFTSHR | |
| SCHEMBL23056923 | 0.80 | GLA (0.44) | ENPP2GSK3BTSHRCLK4S1PR1 | |
| SCHEMBL320196 | 0.80 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL214901 | 0.80 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL7353228 | 0.80 | TSHR (0.57) | ENPP2GSK3BGRM4TNFTSHR | |
| SCHEMBL4095529 | 0.80 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3184526-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AS JANUS KINASE INHIBITOR | Incyte Holdings Corporation (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2426129-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-03-07 | — | — | EP | disclosed |