Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11601220 | 0.87 | ENPP2 (0.48) | ENPP2GSK3BGRM4TSHRTNF | |
| SCHEMBL29857813 | 0.83 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL214901 | 0.83 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL14686260 | 0.83 | GRM4 (0.49) | ENPP2GSK3BGRM4TSHRTNF | |
| SCHEMBL7353228 | 0.83 | TSHR (0.57) | ENPP2GSK3BGRM4TSHRTNF | |
| SCHEMBL320196 | 0.83 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL4095529 | 0.83 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL27948985 | 0.83 | GSK3B (0.51) | ENPP2GSK3BGRM4TSHRTNF | |
| SCHEMBL30583447 | 0.83 | ENPP2 (0.46) | ENPP2GSK3BGRM4TNFS1PR1 | |
| SCHEMBL171656 | 0.83 | ENPP2 (0.46) | ENPP2GSK3BGRM4TSHRTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167074-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF, USE THEREOF, AND INTERMEDIATE THEREOF | FUJIFILM CORPORATION (JP) | 2023-06-01 | — | — | US | disclosed |
| US-20230167074-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF, USE THEREOF, AND INTERMEDIATE THEREOF | FUJIFILM CORPORATION (JP) | 2023-06-01 | — | — | US | disclosed |
| EP-3472137-A1 | PROCESS FOR PREPARING ATALUREN AND ITS INTERMEDIATES | ScinoPharm Taiwan, Ltd. (TW) | 2019-04-24 | — | — | EP | disclosed |
| US-10138215-B2 | Process for preparing ataluren and its intermediates | SCINOPHARM TAIWAN, LTD. (TW) | 2018-11-27 | — | — | US | disclosed |
| WO-2017222474-A1 | PROCESS FOR PREPARING ATALUREN AND ITS INTERMEDIATES | SCINOPHARM TAIWAN, LTD. (TW) | 2017-12-28 | — | — | WO | disclosed |
| US-20170362192-A1 | PROCESS FOR PREPARING ATALUREN AND ITS INTERMEDIATES | SCINOPHARM TAIWAN, LTD. (TW) | 2017-12-21 | — | — | US | disclosed |
| CN-105693971-B | Thermoplastic polyurethane elastomer and preparation method thereof | 上海益弹新材料有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-105693971-A | Thermoplastic polyurethane elastomer and preparation method thereof | 上海益弹新材料有限公司 | 2016-06-22 | — | — | CN | disclosed |
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| EP-1463501-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6617346-B1 | Inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity | HOFFMANN-LA ROCHE INC. | 2003-09-09 | — | — | US | disclosed |
| WO-2003051360-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167074-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF, USE THEREOF, AND INTERMEDIATE THEREOF | DHRS9, DHODH, CBR1 | ENPP2 3174/4885GSK3B 4016/4885GRM4 2252/4885 |
| US-20170362192-A1 | PROCESS FOR PREPARING ATALUREN AND ITS INTERMEDIATES | AGT, AGTR1, GRHPR | ENPP2 1822/4885GSK3B 4624/4885GRM4 2948/4885 |
| US-10138215-B2 | Process for preparing ataluren and its intermediates | AGT, AGTR1, GRHPR | ENPP2 1822/4885GSK3B 4624/4885GRM4 2948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.