Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21987513 | 0.77 | STAT3 (0.41) | STAT3CYP2D6CYP1A2ALDH1A1CYP2C9 | |
| SCHEMBL21987509 | 0.77 | STAT3 (0.41) | STAT3CYP2D6CYP1A2ALDH1A1CYP2C9 | |
| SCHEMBL29156298 | 0.76 | ALDH1A1 (0.40) | STAT3CYP2D6CYP1A2ALDH1A1CYP2C9 | |
| SCHEMBL29156227 | 0.76 | ALDH1A1 (0.40) | STAT3CYP2D6CYP1A2ALDH1A1CYP2C9 | |
| SCHEMBL29156224 | 0.76 | ALDH1A1 (0.40) | STAT3CYP2D6CYP1A2ALDH1A1CYP2C9 | |
| SCHEMBL13738496 | 0.76 | ALDH1A1 (0.45) | STAT3CYP2D6CYP1A2ALDH1A1KMT2A | |
| SCHEMBL13740063 | 0.76 | ALDH1A1 (0.45) | STAT3CYP2D6CYP1A2ALDH1A1KMT2A | |
| SCHEMBL7000711 | 0.76 | ALDH1A1 (0.45) | STAT3CYP2D6CYP1A2ALDH1A1KMT2A | |
| SCHEMBL23705651 | 0.75 | STAT3 (0.44) | STAT3CYP2D6CYP1A2ALDH1A1CYP2C9 | |
| SCHEMBL25307250 | 0.75 | CYP2D6 (0.40) | STAT3CYP2D6CYP1A2ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152690-B1 | PYRIDYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-01-11 | — | — | EP | disclosed |
| US-20110165632-A1 | Process for the Preparation of an Orexin Receptor Antagonist | MERCK SHARP & DOHME LLC | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165632-A1 | Process for the Preparation of an Orexin Receptor Antagonist | HCRTR2, HCRTR1, OXTR | STAT3 4546/4885CYP2D6 2372/4885CYP1A2 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.