Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18636854 | 1.00 | LMNA (0.40) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL17169302 | 0.83 | LMNA (0.36) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL18636691 | 0.82 | LMNA (0.33) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL17169468 | 0.80 | LMNA (0.39) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL21677228 | 0.80 | LMNA (0.39) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL18683370 | 0.80 | CTSS (0.40) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL18683500 | 0.80 | LMNA (0.39) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL18623895 | 0.79 | LMNA (0.38) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL18636851 | 0.78 | LMNA (0.38) | LMNAPOLBCTSSCTSKAAK1 | |
| SCHEMBL17169209 | 0.78 | LMNA (0.39) | LMNAPOLBCTSSCTSKAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015156421-A1 | DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2015-10-15 | — | — | WO | disclosed |