Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.40 |
| ▸ | CHRNG | P07510 | 4/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.40 |
| ▸ | CHRND | Q07001 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289160 | 1.00 | SLC6A3 (0.44) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL43590 | 1.00 | SLC6A3 (0.44) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL43589 | 1.00 | SLC6A3 (0.44) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| Hydrochloric Acid SCHEMBL29399049 | 0.97 | SLC6A3 (0.42) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| Hydrochloric Acid SCHEMBL8190787 | 0.97 | SLC6A3 (0.42) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| Hydrochloric Acid SCHEMBL8190786 | 0.97 | SLC6A3 (0.42) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2946675 | 0.85 | SLC6A3 (0.36) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2946672 | 0.85 | SLC6A3 (0.36) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL24766215 | 0.84 | MME (0.48) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL20677212 | 0.84 | MME (0.48) | SLC6A3SLC6A2CHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713780-B1 | NOVEL INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2012-01-18 | — | — | EP | disclosed |
| EP-2338490-A2 | Combinations Useful for the Treatment of Neuronal Disorders | Probiodrug AG (DE) | 2011-06-29 | — | — | EP | disclosed |
| US-7897633-B2 | Neuronal disorders such as Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function; alcoholism | PROBIODRUG AG (DE) | 2011-03-01 | — | — | US | disclosed |