Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ASGR1 | P07306 | 1/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17173156 | 1.00 | HSD11B1 (0.41) | HSD11B1ASGR1KDM4DBUB1CHRM2 | |
| SCHEMBL31236410 | 0.84 | HSD11B1 (0.44) | HSD11B1ASGR1KDM4DBUB1CHRM2 | |
| SCHEMBL15739423 | 0.82 | HSD11B1 (0.41) | HSD11B1ASGR1KDM4DCHRM2CHRM1 | |
| SCHEMBL16081763 | 0.80 | HSD11B1 (0.44) | HSD11B1ASGR1KDM4DBUB1CHRM2 | |
| SCHEMBL21502038 | 0.80 | TSHR (0.33) | — | |
| SCHEMBL24439134 | 0.80 | HSD11B1 (0.44) | HSD11B1ASGR1KDM4DBUB1CHRM2 | |
| SCHEMBL13567986 | 0.80 | HSD11B1 (0.44) | HSD11B1ASGR1KDM4DBUB1CHRM2 | |
| SCHEMBL22822421 | 0.80 | HSD11B1 (0.44) | HSD11B1ASGR1KDM4DBUB1CHRM2 | |
| SCHEMBL17184415 | 0.80 | HSD11B1 (0.44) | HSD11B1ASGR1KDM4DBUB1CHRM2 | |
| SCHEMBL26645926 | 0.80 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260439-B2 | Dihydropyrrolopyrimidine derivatives | PFIZER INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | PFIZER (US) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | DPYD, TPD52L2, DTYMK | HSD11B1 4200/4885ASGR1 4359/4885KDM4D 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.