Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | GSK3B | P49841 | 4/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PRKACA | P17612 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17178377 | 0.84 | ROCK2 (0.49) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL4288764 | 0.82 | ROCK2 (0.63) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL16241021 | 0.67 | ROCK2 (0.72) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL4297819 | 0.66 | ROCK2 (0.72) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL3640320 | 0.65 | ROCK2 (0.71) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL6644562 | 0.62 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL16586073 | 0.61 | NTRK1 (1.00) | KDM4EALDH1A1HPGDHSD17B10NTRK1 | |
| SCHEMBL3636482 | 0.61 | GSK3B (0.71) | ROCK2GSK3BCDC7PIM1PRKACA | |
| SCHEMBL6642533 | 0.61 | ALDH1A1 (0.65) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 | |
| SCHEMBL14709960 | 0.60 | KDM4E (0.59) | KDM4EALDH1A1HPGDCYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163007-B2 | 5-substituted indazoles as kinase inhibitors | ABBVIE INC. (US) | 2015-10-20 | — | — | US | claimed |