Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.50 |
| ▸ | TACR2 | P21452 | 5/20 | 0.42 |
| ▸ | TACR3 | P29371 | 5/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718066 | 0.94 | HTR7 (0.49) | HTR7TACR2TACR3OPRM1MAPT | |
| SCHEMBL1724094 | 0.90 | TACR3 (0.44) | HTR7TACR2TACR3OPRM1 | |
| SCHEMBL1717488 | 0.87 | HTR7 (0.49) | HTR7TACR2TACR3OPRM1HTR2A | |
| SCHEMBL1717750 | 0.87 | HTR7 (0.43) | HTR7TACR2TACR3OPRM1 | |
| SCHEMBL1717543 | 0.86 | HTR7 (0.46) | HTR7TACR2TACR3OPRM1MAPT | |
| SCHEMBL1718231 | 0.86 | TACR3 (0.49) | TACR2TACR3OPRM1 | |
| SCHEMBL1717610 | 0.85 | HTR7 (0.49) | HTR7TACR3HTR2C | |
| SCHEMBL1718018 | 0.85 | TACR3 (0.43) | HTR7TACR2TACR3OPRM1HTR2A | |
| SCHEMBL1717859 | 0.85 | TACR3 (0.48) | TACR2TACR3OPRM1 | |
| SCHEMBL1717555 | 0.85 | TACR3 (0.48) | TACR2TACR3OPRM1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150534-B1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2012-01-11 | — | — | EP | claimed |
| EP-2150534-B1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2012-01-11 | — | — | EP | disclosed |