Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.62 |
| ▸ | CASP1 | P29466 | 3/20 | 0.61 |
| ▸ | CASP7 | P55210 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | PTGES | O14684 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719847 | 0.89 | MAPT (0.66) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1718013 | 0.88 | PTGES (0.60) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1718702 | 0.88 | ALDH1A1 (0.64) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1719658 | 0.87 | MAPT (0.71) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1718052 | 0.86 | ALDH1A1 (0.61) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1718898 | 0.84 | MAPT (0.62) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1720004 | 0.84 | HPGD (0.59) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1718470 | 0.83 | PTGES (0.67) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1719266 | 0.83 | MAPT (0.78) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1718851 | 0.83 | MAPT (0.68) | ALDH1A1HPGDCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |