Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | CASP1 | P29466 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719162 | 0.91 | KDM4E (0.70) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1719406 | 0.88 | KDM4E (0.69) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1717864 | 0.86 | ALDH1A1 (0.75) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1719980 | 0.85 | ALDH1A1 (0.57) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1719624 | 0.84 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1718948 | 0.84 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL12239908 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1718997 | 0.82 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDCYP3A4CYP2C19 | |
| SCHEMBL1719199 | 0.82 | ALDH1A1 (0.71) | KDM4EALDH1A1HPGDNPSR1CYP1A2 | |
| SCHEMBL1719032 | 0.82 | KDM4E (0.79) | KDM4EALDH1A1HPGDNPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |