Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 14/20 | 0.58 |
| ▸ | TLR7 | Q9NYK1 | 17/20 | 0.55 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4238521 | 0.92 | TLR8 (0.62) | TLR8TLR7NUDT1ADORA3ADORA2A | |
| SCHEMBL17181528 | 0.84 | TLR7 (0.52) | TLR8TLR7NUDT1 | |
| SCHEMBL18179114 | 0.78 | TLR7 (0.79) | TLR8TLR7NUDT1 | |
| SCHEMBL4238517 | 0.77 | TLR8 (0.61) | TLR8TLR7NUDT1NCF1 | |
| SCHEMBL5111244 | 0.74 | TLR8 (1.00) | TLR8TLR7NUDT1 | |
| SCHEMBL1616206 | 0.73 | TLR8 (0.84) | TLR8TLR7NUDT1 | |
| Hydrochloric Acid SCHEMBL6493853 | 0.72 | TLR8 (0.82) | TLR8TLR7NUDT1 | |
| Hydrochloric Acid SCHEMBL3863644 | 0.72 | TLR8 (0.82) | TLR8TLR7NUDT1 | |
| SCHEMBL1952956 | 0.71 | TLR8 (0.80) | TLR8TLR7NUDT1 | |
| SCHEMBL30954539 | 0.71 | TLR8 (0.80) | TLR8TLR7NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447097-B2 | 4-amino-imidazoquinoline compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-20160222010-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2016-08-04 | — | — | US | disclosed |
| US-9334268-B2 | 4-amino-imidazoquinoline compounds | HOFFMAN-LA ROCHE INC. (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150299194-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222010-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | TLR4, TLR1, TLR5 | TLR8 9/4885TLR7 4/4885NUDT1 2019/4885 |
| US-20150299194-A1 | 4-AMINO-IMIDAZOQUINOLINE COMPOUNDS | TLR4, TLR1, TLR5 | TLR8 9/4885TLR7 4/4885NUDT1 2019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.