Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.73 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | CASP1 | P29466 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | THRB | P10828 | 5/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823135 | 0.90 | MAPT (0.78) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1719059 | 0.87 | MAPT (0.80) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1719343 | 0.87 | ALDH1A1 (0.68) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1718398 | 0.87 | MAPT (0.75) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1719213 | 0.86 | THRB (0.73) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1720237 | 0.86 | MAPT (0.80) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1719196 | 0.85 | MAPT (0.80) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1718145 | 0.85 | MAPT (0.77) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1719450 | 0.84 | MAPT (0.77) | MAPTHPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL1719651 | 0.84 | MAPT (0.74) | MAPTHPGDKDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |