Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718562 | 0.89 | ALDH1A1 (0.58) | ALDH1A1KDM4EKMT2ALMNAMEN1 | |
| SCHEMBL1718686 | 0.85 | ALDH1A1 (0.58) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL1718176 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4EKMT2ALMNAHPGD | |
| SCHEMBL1719255 | 0.84 | ALDH1A1 (0.57) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL1717900 | 0.84 | ALDH1A1 (0.73) | ALDH1A1KDM4EKMT2ALMNAMEN1 | |
| SCHEMBL1718568 | 0.83 | KDM4E (0.65) | ALDH1A1KDM4EKMT2ALMNAMEN1 | |
| SCHEMBL1718712 | 0.83 | ALDH1A1 (0.72) | ALDH1A1KDM4EKMT2ALMNAMEN1 | |
| SCHEMBL4204381 | 0.82 | KDM4E (0.69) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL1718578 | 0.82 | ALDH1A1 (0.71) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL1719435 | 0.81 | KMT2A (0.60) | ALDH1A1KDM4EKMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |