SCHEMBL1718176

SCHEMBL1718176

CN(Cc1ccccc1)C(=O)c1nn2c(C(F)(F)F)cc(-c3ccc(F)cc3)nc2c1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.57
NPSR1 Q6W5P4 4/20 0.57
KDM4E B2RXH2 4/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
TDP1 Q9NUW8 2/20 0.57
HTT P42858 1/20 0.57
USP2 O75604 1/20 0.53
MAPT P10636 4/20 0.52
KMT2A Q03164 1/20 0.52
GAA P10253 3/20 0.52
CASP1 P29466 2/20 0.52
THRB P10828 1/20 0.49
MAPK1 P28482 1/20 0.48
APOBEC3A P31941 1/20 0.48
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 2/20 0.47
HPGD P15428 2/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
CASP7 P55210 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1718686 0.94 ALDH1A1 (0.58) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1719255 0.93 ALDH1A1 (0.57) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1718578 0.91 ALDH1A1 (0.71) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1718881 0.85 USP2 (0.60) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1718712 0.84 ALDH1A1 (0.72) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1718366 0.84 ALDH1A1 (0.57) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1718207 0.84 RXFP1 (0.64) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1718886 0.82 USP2 (0.51) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1719998 0.82 USP2 (0.53) ALDH1A1NPSR1KDM4EL3MBTL1TDP1
SCHEMBL1719694 0.81 USP2 (0.51) ALDH1A1NPSR1KDM4EL3MBTL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506196-B1 PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS ICAGEN INC (US) 2012-01-18 EP claimed
EP-1506196-B1 PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS ICAGEN INC (US) 2012-01-18 EP disclosed