Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 8/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718736 | 0.92 | THRB (0.83) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1719243 | 0.91 | MAPT (0.83) | THRBMAPTKDM4EHSD17B10RAB9A | |
| SCHEMBL1718510 | 0.91 | THRB (0.85) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1719908 | 0.89 | MAPT (0.68) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1718673 | 0.87 | KDM4E (0.66) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1718639 | 0.86 | MAPT (0.84) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1718868 | 0.85 | MAPT (0.77) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1718532 | 0.85 | THRB (0.84) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1718632 | 0.84 | THRB (0.75) | THRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1718195 | 0.84 | MAPT (0.74) | THRBMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |