Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | TTR | P02766 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718752 | 0.91 | MAPT (0.75) | KDM4EALDH1A1TTRTHRBMAPT | |
| SCHEMBL1720199 | 0.91 | THRB (0.77) | KDM4EALDH1A1TTRTHRBMAPT | |
| SCHEMBL1719908 | 0.90 | MAPT (0.68) | KDM4EALDH1A1THRBMAPTTP53 | |
| SCHEMBL1719994 | 0.89 | MAPT (0.76) | KDM4EALDH1A1TTRTHRBMAPT | |
| SCHEMBL1718384 | 0.87 | THRB (0.71) | KDM4EALDH1A1THRBMAPTTP53 | |
| SCHEMBL1718510 | 0.86 | THRB (0.85) | KDM4EALDH1A1THRBMAPTTP53 | |
| SCHEMBL1717693 | 0.86 | MAPT (0.73) | KDM4EALDH1A1TTRTHRBMAPT | |
| SCHEMBL1718326 | 0.85 | THRB (0.74) | KDM4EALDH1A1TTRTHRBMAPT | |
| SCHEMBL1719213 | 0.85 | THRB (0.73) | KDM4EALDH1A1TTRTHRBMAPT | |
| SCHEMBL1718850 | 0.85 | TTR (0.76) | KDM4EALDH1A1TTRTHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |