Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.31 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9453333 | 0.80 | TSHR (0.42) | TSHR | |
| SCHEMBL27908434 | 0.80 | TSHR (0.38) | TSHR | |
| SCHEMBL5879391 | 0.79 | TSHR (0.38) | TSHRALDH1A1ZDHHC20ZDHHC2 | |
| SCHEMBL9045147 | 0.78 | TSHR (0.37) | TSHRALDH1A1ZDHHC20ZDHHC2 | |
| SCHEMBL9237767 | 0.76 | TSHR (0.38) | TSHR | |
| SCHEMBL11857578 | 0.74 | TSHR (0.41) | TSHRALDH1A1 | |
| SCHEMBL4058604 | 0.74 | ALDH1A1 (0.36) | TSHRALDH1A1 | |
| SCHEMBL23132563 | 0.73 | TSHR (0.44) | TSHRALDH1A1 | |
| SCHEMBL21048939 | 0.73 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL4791142 | 0.73 | TSHR (0.44) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10857121-B2 | Use of malononitrile compounds for protecting animals from parasites | MERIAL INC. (US) | 2020-12-08 | — | — | US | claimed |
| EP-3131398-B1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2019-10-23 | — | — | EP | claimed |
| EP-3131398-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | Merial, Inc. (US) | 2017-02-22 | — | — | EP | claimed |
| US-20170027899-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | MERIAL INC. (US) | 2017-02-02 | — | — | US | claimed |
| WO-2015161224-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | MERIAL, INC. (US) | 2015-10-22 | — | — | WO | claimed |
| US-10857121-B2 | Use of malononitrile compounds for protecting animals from parasites | MERIAL INC. (US) | 2020-12-08 | — | — | US | disclosed |
| US-10857121-B2 | Use of malononitrile compounds for protecting animals from parasites | MERIAL INC. (US) | 2020-12-08 | — | — | US | disclosed |
| EP-3131398-B1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2019-10-23 | — | — | EP | disclosed |
| CN-104869826-B | Malononitrile compound for preventing and treating animal pest | 巴斯夫欧洲公司 | 2017-08-29 | — | — | CN | disclosed |
| EP-3131398-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | Merial, Inc. (US) | 2017-02-22 | — | — | EP | disclosed |
| EP-3131398-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | Merial, Inc. (US) | 2017-02-22 | — | — | EP | disclosed |
| CN-106455560-A | Use of malononitrile compounds for protecting animals from parasites | 梅里亚股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| US-20170027899-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | MERIAL INC. (US) | 2017-02-02 | — | — | US | disclosed |
| US-20170027899-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | MERIAL INC. (US) | 2017-02-02 | — | — | US | disclosed |
| WO-2015161224-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | MERIAL, INC. (US) | 2015-10-22 | — | — | WO | disclosed |
| WO-2015161224-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | MERIAL, INC. (US) | 2015-10-22 | — | — | WO | disclosed |
| CN-104869826-A | Malononitrile compounds for controlling animal pests | BASF SE | 2015-08-26 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10857121-B2 | Use of malononitrile compounds for protecting animals from parasites | MAL2, NAT1, ME1 | TSHR 4369/4885ALDH1A1 43/4885ZDHHC20 1261/4885 |
| US-20170027899-A1 | USE OF MALONONITRILE COMPOUNDS FOR PROTECTING ANIMALS FROM PARASITES | MAL2, NAT1, ME1 | TSHR 4369/4885ALDH1A1 43/4885ZDHHC20 1261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.