SCHEMBL171856

SCHEMBL171856

C=C1NC=C(c2cccc(NC(=O)c3ccc4c(ccn4C)c3)c2C)C=C1N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 2/20 0.42
HDAC1 Q13547 2/20 0.42
MAOB P27338 1/20 0.41
MAPK14 Q16539 2/20 0.38
MAPK11 Q15759 1/20 0.38
MAPT P10636 3/20 0.38
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
HPGD P15428 1/20 0.38
CYP2C19 P33261 1/20 0.38
KDM1A O60341 1/20 0.37
BTK Q06187 3/20 0.35
AURKA O14965 1/20 0.35
LCK P06239 1/20 0.34
KDR P35968 1/20 0.34
JAK3 P52333 1/20 0.34
CHRNA7 P36544 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL171973 0.80 BTK (0.52) ALDH1A1KDM4EBTKNPC1RAB9A
SCHEMBL13894049 0.70 BTK (0.43) HDAC3HDAC1MAOBMAPTALDH1A1
SCHEMBL108970 0.69 BTK (0.59) MAOBMAPTALDH1A1KDM4ECYP1A2
SCHEMBL1995821 0.64 MAOB (0.59) HDAC3HDAC1MAOBCHRNA7
SCHEMBL30547775 0.64 MAOB (0.59) HDAC3HDAC1MAOBCHRNA7
SCHEMBL8775403 0.63 MAOB (0.69) HDAC3HDAC1MAOBMAPTKDM4E
SCHEMBL16131037 0.63 MAOB (0.60) HDAC3HDAC1MAOBCHRNA7
SCHEMBL8569571 0.63 MAOB (0.60) HDAC3HDAC1MAOBCYP3A4HPGD
SCHEMBL8769745 0.63 MAOB (0.72) HDAC3HDAC1MAOBMAPTKDM4E
SCHEMBL1663116 0.63 MAOB (0.72) MAOBMAPK14MAPK11MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2426109-A1 NOVEL KINASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2012-03-07 EP disclosed