Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718865 | 0.93 | PTGES (0.69) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1720203 | 0.91 | MAPT (0.60) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1719692 | 0.90 | PTGES (0.66) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1719548 | 0.88 | PTGES (0.64) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1718414 | 0.87 | PTGES (0.65) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1717929 | 0.86 | PTGES (0.64) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1718060 | 0.84 | PTGES (0.69) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1718761 | 0.84 | MAPT (0.69) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1719241 | 0.84 | PTGES (0.64) | PTGESMAPTGAAL3MBTL1RXFP1 | |
| SCHEMBL1718417 | 0.84 | RXFP1 (0.66) | PTGESMAPTRXFP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |