Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.70 |
| ▸ | HPGD | P15428 | 11/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.70 |
| ▸ | CASP1 | P29466 | 6/20 | 0.70 |
| ▸ | CASP7 | P55210 | 6/20 | 0.70 |
| ▸ | KLK7 | P49862 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 8/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | USP2 | O75604 | 4/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4197490 | 0.87 | KDM4E (0.74) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL1718960 | 0.86 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL1718295 | 0.86 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL1718993 | 0.85 | KDM4E (0.71) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL4211222 | 0.84 | ALDH1A1 (0.69) | KDM4EALDH1A1HPGDHSD17B10KLK7 | |
| SCHEMBL1719204 | 0.82 | ALDH1A1 (0.70) | KDM4EALDH1A1HPGDHSD17B10KLK7 | |
| SCHEMBL4210939 | 0.82 | KDM4E (0.66) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL4207198 | 0.81 | HPGD (0.76) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL4204177 | 0.80 | KDM4E (0.70) | KDM4EALDH1A1HPGDHSD17B10CASP1 | |
| SCHEMBL4200688 | 0.79 | KDM4E (0.62) | KDM4EALDH1A1HPGDHSD17B10CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |