Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 12/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | KLK7 | P49862 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4211222 | 0.91 | ALDH1A1 (0.69) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL4197490 | 0.90 | KDM4E (0.74) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL1718295 | 0.89 | KDM4E (0.72) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL1718960 | 0.88 | KDM4E (0.72) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL4210939 | 0.87 | KDM4E (0.66) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL4206718 | 0.86 | HSD17B10 (0.84) | KDM4EALDH1A1HPGDNPSR1SMN1; SMN2 | |
| SCHEMBL1718653 | 0.85 | KDM4E (0.70) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL1719204 | 0.85 | ALDH1A1 (0.70) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL4204177 | 0.84 | KDM4E (0.70) | KDM4EALDH1A1HTTAPOBEC3AHPGD | |
| SCHEMBL3277995 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1HTTAPOBEC3AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |