Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.86 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718373 | 0.93 | POLB (1.00) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL1719219 | 0.79 | POLB (0.65) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3283065 | 0.76 | TDP1 (0.60) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL19148277 | 0.70 | TDP1 (0.54) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL5576498 | 0.69 | RAB9A (0.55) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL23534262 | 0.68 | POLB (0.52) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL4206864 | 0.68 | TDP1 (0.57) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL23534535 | 0.68 | TDP1 (0.51) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL1718574 | 0.68 | RECQL (0.74) | POLBTDP1SMN1; SMN2MAPTKDM4E | |
| Benzylamine SCHEMBL1719444 | 0.68 | POLB (0.51) | POLBTDP1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |